Potential anti-allergic ent-kaurene diterpenes from the bark of Suregada multiflora
2006
Cheenpracha, S. | Yodsaoue, O. | Karalai, C. | Ponglimanont, C. | Subhadhirasakul, S. | Tewtrakul, S. | Kanjana-opas, A.
Two ent-kaurene diterpenes, ent-16-kaurene-3β,15β,18-triol (1) and ent-3-oxo-16-kaurene-15β,18-diol (2), were isolated from a dichloromethane extract of the bark of Suregada multiflora along with five known diterpenes:ent-16-kaurene-3β,15β-diol (3), abbeokutone (4), helioscopinolide A (5), helioscopinolide C (6) and helioscopinolide I (7). Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1-7 possessed appreciable anti-allergic activities in RBL-2H3 cells model with IC50 values ranging from 22.5 to 42.2 μM.
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