Catalytic asymmetric synthesis of O-acetyl cyanohydrins from KCN, Ac₂O and aldehydes
2002
Belokon, Yuri N. | Gutnov, Andrey V. | Moskalenko, Margarita A. | Yashkina, Lidia V. | Lesovoy, Denis E. | Ikonnikov, Nicolai S. | Larichev, Vladimir S. | North, Michael
A (salen)titanium catalyst has been found to induce the asymmetric addition of potassium cyanide and acetic anhydride to aldehydes, giving enantiomerically enriched cyanohydrin esters with up to 92% enantiomeric excess using just 1 mol% of the catalyst. This is the first report of the asymmetric synthesis of cyanohydrin derivatives using a cyanide source which is non-volatile and inexpensive.
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