Cytochalasin P₁, a new cytochalasin from the marine-derived fungus Xylaria sp. SOF11
2017
Chen, Ziming | Chen, Yuchan | Huang, Hongbo | Yang, Hongyan | Zhang, Weimin | Sun, Yulin | Wen, Jing
A new cytochalasin, named cytochalasin P₁ (1), together with four known analogs (2–5) was isolated from marine-derived fungus Xylaria sp. SOF11 from the South China Sea. The structure of the new compound was elucidated on the basis of MS and NMR (¹H, ¹³C, HSQC, HMBC, and NOESY) data analyses. Compounds 1–5 were tested for their cytotoxicities against four tumor cell lines (SF-268, MCF-7, NCI-H460, and HepG-2). Compounds 1–5 showed significant cytotoxicity against two tumor cell lines MCF-7 and SF-268, with the IC₅₀ values varying between 0.33 and 4.17 μM.
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