Excipient-free pulmonary insulin dry powder: Pharmacokinetic and pharmacodynamics profiles in rats
2020
Quarta, Eride | Chierici, Veronica | Flammini, Lisa | Tognolini, Massimiliano | Barocelli, Elisabetta | Cantoni, Anna Maria | Dujovny, Gabriela | Ecenarro Probst, Susana | Sonvico, Fabio | Colombo, Gaia | Rossi, Alessandra | Bettini, Ruggero | Colombo, Paolo | Buttini, Francesca
A novel pure insulin spray-dried powder for DPI product (Ins_SD) was studied with respect to physico-chemical stability, in vitro respirability, bioavailability, activity and tolerability.Ins_SD powder exhibited a very high in vitro respirability, independently of the DPI product preparation (manual or semi-automatic). Physico-chemical characteristics of Ins_SD powder remained within the pharmacopoeia limits during 6 months of storage at room temperature.PK/PD profiles were measured in rats that received the pulmonary powders by intratracheal insufflation and compared with Afrezza inhalation insulin. Due to the low drug powder mass to deliver, both insulin powders were diluted with mannitol. Insulin from Ins_SD was promptly absorbed (tₘₐₓ 15 min and Cₘₐₓₓ4.9 ± 1.5 mU/ml). Afrezza had a slower absorption (tₘₐₓ 30 min and Cₘₐₓ of 1.8 ± 0.37 mU/ml). After glucose injection, Ins_SD determined a rapid reduction of glucose level, similar to Afrezza. As reference, insulin subcutaneous injection showed a long-lasting hypoglycemic effect due to the slow absorption that prolonged insulin plasma level.In summary, Ins_SD product is suitable for post-prandial glucose control, providing a convenient and compliant product, in particular in the event of using a disposable device.Albeit the product has to be stored in fridge, its stability at room temperature allows the diabetic individual to carry the daily dose in normal conditions.
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