A new anti-inflammatory lignan from Lonicerae Japonicae flos
2021
Yang, Ran | Fang, Lei | Li, Jia | Zhang, Yong-Qing
One new lignan, loniceralanside A (1), together with three known compounds (2–4), were purified from Lonicerae Japonicae Flos. Their structures were determined by HR-ESI-MS, 1 D and 2 D NMR data. Compounds 2–4 were separated from the plant for the first time. The biological test showed that compound 1 had significant anti-inflammatory activity with inhibiting the release of β-glucuronidase induced by platelet-activating factor (PAF) in rat polymorphonuclear leukocytes (PMNs) (IC₅₀ = 3.05 µM).
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