Fat cells lipogenesis from dietary obese rats fed high fat or high carbohydrate diet. I. Glucose, pyruvate and acetate metabolism
1979
Louis, S.L. | Davis, G.
Sprague-Dawley dietary obese rats were fed high fat (HF) or high carbohydrate (HC) diets from weaning age to four or eight weeks. Both diets had the same digestible energy content. The isolated fat cells sensitivity to insulin and lipid synthesis from glucose, pyruvate and acetate was studied. Adipose cells from weanlings had greater sensitivity to insulin than the adults on either diet, but HC cells were more sensitive than HF cells. Lipogenesis was lower in HF and higher in HC rats. Pyruvate was incorporated into lipids at the highest rate, acetate the lowest. Acetate utilization was enhanced in all HC cells. The incorporation of glucose into glycerol was higher in obese rats than in lean litter mates of the same age. Re-esterification was an activated pathway of lipogenesis during obesity as it occurred in lean rats fed high fat diet.
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