Synthesis and analgesic activity of (2,3-diphenyl-1H-indol-5-YL)piperazin-1-yl methanone derivatives
2009
El-Nezhawy, A. O. H | El-Naem, S. I | Galal, S. A | El-Diwani, H. I | Abdel Salam, O. M. E | Baiomy, A. R
Series of 1,4-disubstituted piperazine and of N,N-disubstituted ethylenediamine having the 2,3-diphenyl- 1H-indole-5-carbonyl group as one of the two substituents were prepared. Compounds 3, 4, 11, 15 - 17, and 20 - 22 were tested for analgesic activity. After ip administration all compounds induced significant visceral antinociceptive activities where acetic acid-induced writhing was significantly reduced by all compounds.
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