Hydrostatic Pressure-Regulated Cellular Calcium Responses
2021
Fukuchi, Minami | Oyama, Kotaro | Mizuno, Hiroaki | Miyagawa, Akihisa | Koumoto, Kazuya | Fukuhara, Gaku
Hydrostatic pressure control has attracted much attention and presents a still challenging objective from mechanobiological viewpoints. Herein, we reveal the calcium entry processes in HeLa cells by means of hydrostatic pressure spectroscopy. The steady-state fluorescence spectral data comprehensively elucidated the factors controlling the outcomes of the hydrostatic pressure-stimulated calcium entry behavior. The present work leads to a new perspective on ion regulations in living cells and an attractive alternative to conventional mechanostimuli.
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