Fetal and Early Postnatal Protein Malnutrition Cause Long-Term Changes in Rat Liver and Muscle Mitochondria

Park, Kyong Soo; Kim, Suk Kyeong; Kim, Min Seon; Cho, Eun Young; Lee, Jong Ho; Lee, Ki-Up; Pak, Youngmi Kim; Le, Hong Kyu

Fetal and Early Postnatal Protein Malnutrition Cause Long-Term Changes in Rat Liver and Muscle Mitochondria

2003

Epidemiologic data suggest a strong association between low birth weight and increased risk of metabolic syndrome in adult life. However, the underlying mechanisms are largely unknown. To test the hypothesis that mitochondrial changes may serve as a link between poor nutrition in early life and insulin resistance in later life, we investigated the effect of protein malnutrition during gestation and lactation on mitochondria of the liver and skeletal muscle. Female offspring of Sprague-Dawley rats fed a low protein diet (casein, 80 g/kg) were randomly divided into two groups and weaned onto either the low protein diet or a control diet (casein, 180 g/kg). As a control group, offspring of rats fed the control diet were weaned onto the control diet. The rats in each group were randomly divided into four groups that were killed at 5, 10, 15 and 20 wk of age. Both mitochondrial DNA content and the expression of mitochondrial DNA-encoded genes in liver and muscle were measured. Mitochondrial transcription factor A and antioxidant enzyme activities were also determined. The mitochondrial DNA content of the liver and skeletal muscle were reduced in fetal and early postnatal malnourished rats even when proper nutrition was supplied after weaning. These changes were accompanied by a decrease in mitochondrial DNA-encoded gene expression; however, they were not dependent on mitochondrial transcriptional factor A. Our findings indicate that poor nutrition in early life causes long-lasting changes in mitochondria that may contribute to the development of insulin resistance in later life.

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Mots clés AGROVOC

aging analysis animals blood body weight casein chemistry dna embryology enzyme activity enzymology gene expression genes genetics kwashiorkor lactation lipid peroxidation liver liver liver metabolism mitochondria mitochondria mitochondria mitochondrial dna muscle muscle pregnancy pregnancy pregnancy complications progeny rats rats rats risk rna superoxide dismutase transcription factors transcription factors ultrastructure weaning

Informations bibliographiques

Publié dans

Journal of nutrition

Volume 133 Numéro 10 Pagination 3085 - 3090 ISSN 0022-3166

Editeur

American Institute of Nutrition

D'autres materias

Complications; Dna-binding proteins; Nuclear proteins; Mitochondrial; Messenger; Low birth weight; Nadh dehydrogenase; Low protein diet; Insulin resistance; Skeletal; Protein deficiency; Female; Skeletal muscle; Metabolic syndrome; Animal nutritional physiological phenomena; Insulin resistance; Mitochondrial proteins; Sprague-dawley; Male; Prenatal exposure delayed effects; Electron transport complex iv

Langue

anglais

Note

Includes references

Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-28

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Fetal and Early Postnatal Protein Malnutrition Cause Long-Term Changes in Rat Liver and Muscle Mitochondria

2003

Mots clés AGROVOC

Informations bibliographiques