Regulation of circadian locomotor rhythm by miR-263a
2022
Nian, Xiaoge | Chen, Wenfeng | Bai, Weiwei | Zhao, Zhangwu
The circadian clock is a rhythmic oscillator driving various physiological and behavioral processes that adapt to daily environmental changes. MicroRNAs (miRNAs) are a class of small non-coding RNAs that play an important role in post-transcriptional regulation. Although recent work has demonstrated that miRNAs are involved in development and disease, their function in the adult circadian locomotor rhythm still needs to be extensively characterized. In this study, we identified the miR-263a as an important regulator of Drosophila circadian locomotor rhythm, with miR-263a expression in LNv clock neurons. The overexpression of miR-263a in clock neurons lengthens the circadian period, while its mutant Bereft²⁴ shortens the circadian period. In addition, downregulation of miR-263a also dramatically attenuates the morning activity peak as well as circadian rhythm robustness. Moreover, slo and homer are identified as the potential targets of the miR-263a. Together, these results establish that the miR-263a is an important regulator of circadian locomotor rhythm.
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