Chiral N-(tert-butyl)-N-methylaniline type ligands: synthesis and application to palladium-catalyzed asymmetric allylic alkylation
2015
Mino, Takashi | Asakawa, Minato | Shima, Yamato | Yamada, Haruka | Yagishita, Fumitoshi | Sakamoto, Masami
We found that N-(tert-butyl)-N-methylanilines 1 have C(aryl)–N(amine) bond axial chirality and succeeded the optical resolution of C–N bond atropisomers of amines 1 by a chiral palladium resolving agent and/or a chiral HPLC method. Finally, we demonstrated the ability of chiral amines 1 as a ligand in palladium-catalyzed asymmetric allylic alkylation of allylic esters with malonates (up to 95% ee).
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