Selective N1-Acylation of Indazoles with Acid Anhydrides Using an Electrochemical Approach
2019
Dissanayake, D. M. M Mevan | Vannucci, Aaron K.
An electrochemical synthesis method for the selective N1-acylation of indazoles has been developed. This “anion pool” approach electrochemically reduces indazole molecules generating indazole anions and H₂. Acid anhydrides are then introduced to the solution resulting in selective acylation of the N1-position of the indazoles. This procedure can also be applied to the acylation of benzimidazoles and indoles. The reaction can also be performed using a 9 V battery without loss of reaction efficiency.
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