Indirect determination of sodium diclofenac, sodium dipyrone and calcium gluconate in injection drugs using digital image-based (webcam) flame emission spectrometric method
2011
da Silva Lyra, Wellington | Castriani Sanches, Fátima Aparecida | Antônio da Silva Cunha, Francisco | Gonçalves Dias Diniz, Paulo Henrique | Lemos, Sherlan Guimarães | Cirino da Silva, Edvan | Ugulino de Araujo, Mario Cesar
This paper proposes a digital image-based flame emission spectrometric (DIB-FES) method for indirect determination of sodium diclofenac, sodium dipyrone and calcium gluconate in injectable forms. The proposed DIB-FES method uses digital images obtained from a webcam, based on the RGB (Red-Green-Blue) system. It offers a simple and inexpensive way to quantify these organic substances using the radiation emitted by the alkaline and earth-alkaline metals present in their formulae. Analytical curves were constructed on the basis of the relationship between RGB values and calibration solution concentrations. The results showed no statistical difference between the proposed and reference methods when applying the paired t-test at a 95% confidence level. The proposed DIB-FES method also performed well in terms of the figures of merit LOD, LOQ, linear range, precision, and the accuracy as revealed by recovery tests.
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