Isoproterenol-induced maximal heart rate in normothermic and hyperthermic horses

Goetz, T.E.; Manohar, M.

Isoproterenol-induced maximal heart rate in normothermic and hyperthermic horses

1990

Goetz, T.E. | Manohar, M.

The heart rate (HR) induced by maximal beta-adrenergic activation, which was elicited by infusion of isoproterenol, was studied in 8 healthy horses before (control) and after hyperthermia was induced by IV administration of 2,4-dinitrophenol (DNP). Isoproterenol was administered IV at 1.0 micrograms.kg-1.min-1 for 3 minutes and the HR was determined during the final 30 seconds of the infusion. As the rectal temperature increased (P < 0.001) from 38.2 +/- 0.1 C (mean +/- SEM; normothermic control) to 40.1 +/- 0.1 C at 60 minutes after DNP administration, the isoproterenol-induced HR also increased from 198 +/- 4 beats/min (control) to 214 +/- 4 beats/min (P < 0.001). It appeared that the values of HR achieved with maximal beta-adrenergic activation were augmented by the hypermetabolic, hyperthermic state induced by DNP.

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Mots clés AGROVOC

animals body temperature body temperature fever fever heart rate heart rate horses horses pharmacology physiology physiopathology

Informations bibliographiques

Publié dans

American journal of veterinary research

Volume 51 Numéro 5 Pagination 743 - 746 ISSN 0002-9645

D'autres materias

Isoproterenol; 4-dinitrophenol; Horse diseases; 4-dinitrophenol; Administration & dosage; Isoprenaline; Time factors; Female; Dinitrophenols; Male; Veterinary; Chemically induced; Drug effects; Infusions; Intravenous

Langue

anglais

Note

2019-12-04

Type

Text; Journal Article

Sur AGRIS depuis: 2024-02-28

Format: MODS

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