Signatures of selection analysis using whole-genome sequence data reveals novel candidate genes for pony and light horse types
2020
Salek Ardestani, Siavash | Aminafshar, Mehdi | Zandi Baghche Maryam, Mohammad Bagher | Banabazi, Mohammad Hossein | Sargolzaei, Mehdi | Miar, Younes
Natural selection and domestication have shaped modern horse populations, resulting in a vast range of phenotypically diverse breeds. Horse breeds are classified into three types (pony, light, and draft) generally based on their body type. Understanding the genetic basis of horse type variation and selective pressures related to the evolutionary trend can be particularly important for current selection strategies. Whole-genome sequences were generated for 14 pony and 32 light horses to investigate the genetic signatures of selection of the horse type in pony and light horses. In the overlapping extremes of the fixation index and nucleotide diversity results, we found novel genomic signatures of selective sweeps near key genes previously implicated in body measurements including C4ORF33, CRB1, CPN1, FAM13A, and FGF12 that may influence variation in pony and light horse types. This study contributes to a better understanding of the genetic background of differences between pony and light horse types.
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