Late effects of premature weaning to different diets in the rat
1978
Hahn, P. | Girard, J. | Assan, J. | Kervran, A. | Koldovsky, O.
Female rats were prematurely weaned on the 18th postnatal day to a high fat (HF) or high carbohydrate (HG) diet. Twelve days later they were all given free access to a cereal based stock diet. When aged 10 months, they were all fed an atherogenic diet for the next 2 months and were then killed. Effects of the diets on blood cholesterol levels, serum glucagon levels, serum insulin levels, selected enzyme activities, and the fat content of adipose tissue are reported. The findings indicate that early weaning in the rat has no obvious late effects as long as the middle-aged adult animal is not challenged with a new stimulus, such as a HF or high cholesterol. Differences do appear when such stimulation is applied.
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