The genome of serotype VI Streptococcus agalactiae serotype VI and comparative analysis
2017
He, En-Ming | Chen, Cheng-Wen | Guo, Yong | Hsu, Mei-Hua | Zhang, Liang | Chen, Hsiu-Ling | Zhao, Guo-Ping | Chiu, Cheng-Hsun | Zhou, Yan
Streptococcus agalactiae (GBS) causes serious infections in humans and other species. A total of 25 complete GBS genomes, including the first sequenced serotype VI genome (GBS-M002), were compared in this study. The power law model suggested that the pan-genome of GBS is open, with approximately 1300 genes in the core genome of GBS, accounting for approximately 60% of the average genome content. GBS-M002 has 73 specific genes and is one of the five strains containing >60 specific genes. Based on COG (Cluster of Orthologous Groups of proteins) functional classification, 24% of the genes related to defense mechanisms are specific among the strains. A phylogenetic tree shows that GBS-M002 is closely related to certain strains of serotypes III and V from humans and to isolates of unknown serotype from dog and bovine hosts, suggesting the universal infection potential of GBS from humans to other mammal and fish hosts.
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