Reformulating cyclosporine A (CsA): More than just a life cycle management strategy

Guada, Melissa; Beloqui, Ana; Kumar, M.N.V Ravi; Préat, Véronique; Dios-Viéitez, Maria del Carmen; Blanco-Prieto, Maria J.

Reformulating cyclosporine A (CsA): More than just a life cycle management strategy

2016

Cyclosporine A (CsA) is a well-known immunosuppressive agent that gained considerable importance in transplant medicine in the late 1970s due to its selective and reversible inhibition of T-lymphocytes. While CsA has been widely used to prevent graft rejection in patients undergoing organ transplant it was also used to treat several systemic and local autoimmune disorders. Currently, the neuro- and cardio-protective effects of CsA (CiCloMulsion®; NeuroSTAT®) are being tested in phase II and III trials respectively and NeuroSTAT® received orphan drug status from US FDA and Europe in 2010. The reformulation strategies focused on developing Cremophor® EL free formulations and address variable bioavailability and toxicity issues of CsA. This review is an attempt to highlight the progress made so far and the room available for further improvements to realize the maximum benefits of CsA.

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Mots clés AGROVOC

bioavailability europe gmo immunosuppressant medicine mp ms np patients pva spc t-lymphocytes tc toxicity

Informations bibliographiques

Publié dans

Journal of controlled release

Volume 225 Pagination 269 - 282 ISSN 0168-3659

Editeur

Elsevier B.V.

D'autres materias

Cremophor® el; Lec; Nlc; Peg-sa; Tween® 20; Mygliol®840; Nmp; Sln; Nanoparticle; Cremophor® rh; Hexpla; Tween® 80; Gcpq; Sdc; Dcm; Cys-peg-sa; Mpeg; Peo n80; Gelucire; Witepsol h15; Pluronic® f68; Plga; Compritol®888; Transcutol p®; Mygliol®812; Dss; Dmab; Drug delivery system; Food and drug administration; Lps; Slm; Asc; Mrt; Cyclosporine; Il; Labrafil m® 1944 cs; El14; Peg; Lipo 320; Capmul mcm; Snedds; Cardioprotective effect; Hpmc k100m; Cyclosporine a; Dynasan 118; Epikuron 200; Precirol ato®5; Csa; Dynasan 116; Ltp; Dynasan 114; Pcl; Hcv; Lipoid e80; Organ transplantation; Pvp k30; Auc; Graft rejection; Dcs; Span 80; Microparticle; Precifac ato®5; Dynasan 110

Langue

anglais

Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-28

Format: MODS

Fournisseur de données

Cette notice bibliographique a été fournie par National Agricultural Library

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Liens

DOI DOI http://dx.doi.org/10.1016/j.jconrel.2016.01.056

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