Application of Ru(II)-Catalyzed Enyne Cyclization in the Synthesis of Brefeldin A
2016
Raghavan, Sadagopan | Yelleni, Mahesh Kumar Rao
The approach to brefeldin A described herein hinges on Ru(II)-catalyzed cycloisomerization of an enyne obtained by the reaction of an alkynylzinc reagent with an α-chloro sulfide. Other key steps include Mislow–Evans rearrangement, cross-metathesis, and macrocyclization using a Roush–Masamune protocol.
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