Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles
2019
Peramo, Arnaud | Dumas, Anaëlle | Remita, Hynd | Benoît, Mireille | Yen-Nicolay, Stephanie | Corre, Raphaël | Louzada, Ruy A. | Dupuy, Corinne | Pecnard, Shannon | Lambert, Benoît | Young, Jacques | Desmaële, Didier | Couvreur, Patrick
We have developed new benign palladium nanoparticles able to catalyze the Suzuki–Miyaura cross-coupling reaction on human thyroglobulin (Tg), a naturally iodinated protein produced by the thyroid gland, in homogenates from patients’ tissues. This represents the first example of a chemoselective native protein modification using transition metal nanoobjects in near-organ medium.
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