Fast and Reliable Quantitative Peptidomics with labelpepmatch
2016
Verdonck, Rik | De Haes, Wouter | Cardoen, Dries | Menschaert, Gerben | Huhn, Tom | Landuyt, Bart | Baggerman, Geert | Boonen, Kurt | Wenseleers, Tom | Schoofs, Liliane
The use of stable isotope tags in quantitative peptidomics offers many advantages, but the laborious identification of matching sets of labeled peptide peaks is still a major bottleneck. Here we present labelpepmatch, an R-package for fast and straightforward analysis of LC–MS spectra of labeled peptides. This open-source tool offers fast and accurate identification of peak pairs alongside an appropriate framework for statistical inference on quantitative peptidomics data, based on techniques from other -omics disciplines. A relevant case study on the desert locust Schistocerca gregaria proves our pipeline to be a reliable tool for quick but thorough explorative analyses.
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