29-kDa: A potential candidate for anti-tick vaccine antigen source as immunogenic and stage reactive targeting hard-bodied Hyalomma ticks (ixodidae)
2021
Kamran, Kashif | Villagra, Cristian A. | Iqbal, Asim | Kakar, Asmatullah | Schapheer, Constaza | Taj, Muhammad Kamran | ʻAlī, ʻĀbid | Siddiqui, Saima
The objective of present study is to develop a vaccine against Hyalomma hard-bodied tick and to analyze relevant experimental data on immunized indigenous horse breed Morna. Montanide (ISA-50) adjuvant-based vaccine induced significantly (p < 0.02) higher antibody titre through intradermal route with 99.98% vaccine efficacy. Humoral response was determined though indirect ELISA; where peak level of serum antibody was recorded after six weeks interval of post-immunization. Most of hematology and biochemical parameters remained consistent to normal reference values. Our report also indicates a significant percentage decline in the numbers of engorged ticks, eggs mass, eggs number and increased tick rejection. The animal travel history can promote tick burden and is a potential risk factor. Based on biological and hematological parameters, it is possible to conclude that 29-kDa antigen can be used as an effective antigen vaccine candidate to control tick infestation detected through humoral response.
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