Decarboxylative coupling of glyoxylic acid and its acetal derivatives: A unique C1 formylation synthon
2021
Xiang, Yunyu | Zeng, Ganfei | Sang, Xiaoyan | Li, Xiaofang | Ding, Qiuping | Peng, Yiyuan
Glyoxylic acid and its acetal derivatives are low toxicity, easy handling and storage, high stability and easy availability. In addition, they are easy to perform decarboxylative cross-coupling reactions. Therefore, the decarboxylative cross-coupling of glyoxylic acid and its acetal derivatives are beginning to emerge. This review mainly focuses on the decarboxylative cross-coupling reactions using glyoxylic acid and its acetal derivatives as formylation agents.
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