Disassociation of bactericidal and fungistatic activities from the oxidative burst of avian macrophages

Harmon, B.G.; Glisson, J.R.

Disassociation of bactericidal and fungistatic activities from the oxidative burst of avian macrophages

1990

Harmon, B.G. | Glisson, J.R.

Avian peritoneal exudate macrophages, when exposed to phagocytic stimuli, produced an appreciable oxidative burst as measured by production of chemiluminescence, superoxide anion, and hydrogen peroxide. Metabolic inhibitors of the oxidative burst and scavengers of oxygen radicals clearly inhibited macrophage chemiluminescence, but had no significant effect on macrophage bactericidal activity against Escherichia coli or fungistatic activity against Candida tropicalis. Therefore, avian macrophages were capable of oxygen-independent bactericidal and fungistatic activities.

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