Evaluating the efficacy of Achillea Millefolium ointment in the treatment of recurrent idiopathic epistaxis; a randomized double-blind clinical trial
2021
Hashemian, Farnaz | Akbarpour, Maliheh | Razaghi, Keyvan | Emam, Amirhossein | Seiferabiei, Mohammadali | Hashemian, Farshad
Epistaxis is one of the most common reasons for patient referral to ear, nose and throat (ENT) clinics and reported to involve 60 % of the total population. This study aimed to evaluate the efficacy of Achillea Millefolium ointment in the treatment of recurrent idiopathic epistaxis. In this randomized, double-blind, placebo-controlled, trial, fifty patients with idiopathic recurrent epistaxis completed the study. Full initial assessments and coagulation tests were performed prior to the study. The patients were randomly divided into two groups of case and control and received "Vitamin A and Achillea Ointment" or "Vitamin A and Placebo ointment" on alternate days respectively (Vitamin A ointment on day 1 and Achillea or Placebo ointment on the next day) for 10 days. Nasal examinations and coagulation tests were carried out on day 10 and patients were visited at the end of first and third month following treatment initiation. The amount of bleeding was recorded by Epistaxis Severity Score (ESS) before and after the intervention (10ᵗʰ Day, 1ˢᵗ and 3ʳᵈ Month). There was no significant difference in frequency and duration of bleeding between two groups on day 10 (p = 0.105). However, a significant reduction in frequency and duration of bleeding was seen in the case group in the first and third month follow-up (p < 0.001). No complications were reported during the treatment in the case group. This study indicated that Achillea ointment 1% was effective in decreasing ESS and duration of bleeding in patients with recurrent idiopathic epistaxis with no detectable side effects.
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