Enzyme-mediated dual-targeted-assembly realizes a synergistic anticancer effect
2019
MangThese authors contribute equally to this work., Dingze | Zhang, Shijin | Wu, Xia | Hu, Xunwu | Mochizuki, Toshiaki | Li, Guanying | Zhang, Ye
We designed and synthesized homochiral-peptide-based boron diketonate complexes. Co-administration of the two stereoisomers in cancer cells led to molecular assembly targeting both the plasma membrane and the lysosomes mediated via membrane-bonded enzymes. The dual-targeted-assembly generates a synergistic anticancer effect with amplified cancer spheroid toxicity and enhanced inhibition efficacy on cancer cell migration.
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