Functional analysis of lymphoid cells from mouse bone marrow in vitro
1978
Rubin, Bent | HØIer‐Madsen, M. | RØPke, Carsten
The present results show that mouse bone marrow (BM) cells responded in vitro against phytohaemagglutinin (PHA), concanavalin A (Con A) and lipopolysaccharide (LPS), In addition, BM cell suspensions contained relatively many cells with ADCC (antibody‐dependent cell‐mediated cytotoxicity) activity. BM cells were fractionated according to various cell surface characteristics. The results of these experiments were compared with previously published reports, showing that pre‐T and pre‐B cells could be separated on Ig anti‐Ig columns (Ig = immunoglobulin). The combined results showed that pre‐T cells may fractionate together with cells with the following characteristics: they displayed ADCC activity and had Fc receptors (FcR) and/or membrane Ig. Pre‐B cells fractionated with cells with the following characteristics‐, they responded to LPS but had no ADCC activity. They were not adherent and/or phagocytic and were Ig‐, FcR‐ and C3 receptor (C3R) negative.
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