Recombinant Strains of Human Parechovirus in Rural Areas in the North of Brazil
2019
Leal, Élcio | Luchs, Adriana | Milagres, Flávio Augusto de Pádua | Komninakis, Shirley Vasconcelos | Gill, Danielle Elise | Lobato, Márcia Cristina Alves Brito Sayão | Brustulin, Rafael | Chagas, Rogério Togisaki das | Abrão, Maria de Fátima Neves dos Santos | Soares, Cássia Vitória de Deus Alves | Villanova, Fabiola | Witkin, Steven S. | Deng, Xutao | Sabino, Ester Cerdeira | Delwart, Eric | Costa, Antônio Charlys da
We characterized the 24 nearly full-length genomes of human parechoviruses (PeV) from children in the north of Brazil. The initial phylogenetic analysis indicated that 17 strains belonged to genotype 1, 5 to genotype 4, and 1 to genotype 17. A more detailed analysis revealed a high frequency of recombinant strains (58%): A total of 14 of our PeV-As were chimeric, with four distinct recombination patterns identified. Five strains were composed of genotypes 1 and 5 (Rec1/5); five strains shared a complex mosaic pattern formed by genotypes 4, 5, and 17 (Rec4/17/5); two strains were composed of genotypes 1 and 17 (Rec1/17); and two strains were composed of genotype 1 and an undetermined strain (Rec1/und). Coalescent analysis based on the Vp1 gene, which is free of recombination, indicated that the recombinant strains most likely arose in this region approximately 30 years ago. They are present in high frequencies and are circulating in different small and isolated cities in the state of Tocantins. Further studies will be needed to establish whether the detected recombinant strains have been replacing parental strains or if they are co-circulating in distinct frequencies in Tocantins.
Afficher plus [+] Moins [-]Mots clés AGROVOC
Informations bibliographiques
Cette notice bibliographique a été fournie par National Agricultural Library
Découvrez la collection de ce fournisseur de données dans AGRIS