Associations between exposure to metal mixtures and birth weight
2020
Yang, Xuefen | Li, Yuanyuan | Li, Juxiao | Bao, Shuangshuang | Zhou, Aifen | Xu, Shunqing | Xia, Wei
Previous epidemiological studies have indicated that prenatal exposure to individual metals affect fetal growth. However, the ordinary linear regression has not enough power to assess the mixture effect of multiple metals and cannot capture the possible differences in associations of metal exposures by subgroups of infant birth weight distribution. To investigate the associations of prenatal exposure to metal mixtures with birth weight, and further to assess whether the sensibilities to metal toxicity are dissimilar among infants with poor and normal fetal growth. A total of 16 metals were analyzed in 736 cord samples from a Chinese birth cohort study. Weighted quantile sum regression (WQSR) found the estimate of the metal mixtures was negatively related to birthweight z-score overall [β (95% CI): −0.31 (−0.42, −0.20)], and the major contributors to the mixture index were Cu (39.7%), Ni (18.3%), Mn (14.0%), and Cd (13.1%). Quantile regression showed stronger relations in the tails of birthweight z-score distribution [e.g. the associations of Cu at specific birth weight z-score quantiles were: 10th percentile −0.70 (95% CI: −1.06, −0.35), the 90th percentile −0.35 (95% CI: −0.63, −0.06)]. Our study found that prenatal exposure to Cu, Mn, Ni, and Cd were negatively linked with birthweight z-score. The associations observed were stronger in the tails of birth weight z-score distribution.
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