The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1 alpha and Drosophila single-minded

Nambu, J.R.; Chen, W.; Hu, S.; Crews, S.T.

The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1 alpha and Drosophila single-minded

1996

Nambu, J.R. | Chen, W. | Hu, S. | Crews, S.T.

The Drosophila melanogaster (Dm) similar (sima) gene was isolated using a low-stringency hybridization screen employing a Dm single-minded gene basic helix-loop-helix (bHLH) DNA probe. sima is a member of the bHLH-PAS gene family and the conceptual protein shares a number of structural features, including a bHLH domain, PAS domain, and homopolymeric amino acid stretches. Sima is most closely related to the human hypoxia-inducible factor 1 alpha bHLH-PAS protein. In situ hybridization experiments reveal that sima is transcribed in most or all cells throughout embryogenesis. It has been cytologically mapped to position 99D on the third chromosome, and is not closely linked to other known bHLH-PAS genes.

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Mots clés AGROVOC

amino acid sequences animals chemistry chromosome mapping chromosome mapping complementary dna dna drosophila melanogaster embryogenesis gene expression gene expression genes genetics humans messenger rna metabolism open reading frames phylogeny transcription factors transcription factors

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Publié dans

Gene

Volume 172 Numéro 2 Pagination 249 - 254 ISSN 0378-1119

D'autres materias

Dna-binding proteins; Dna-binding proteins; Nuclear proteins; Multigene family; Drosophila proteins; Molecular sequence data; Transcription (genetics); Sequence homology; Amino acid; Hypoxia-inducible factor 1; Polytene chromosomes; Sima gene; Amino acid sequence; Genbank/u43090; Basic helix loop helix protein; Alpha subunit; Hypoxia-inducible factor 1; Base sequence; Insect; Transcriptional activators; Nucleotide sequences; Basic helix-loop-helix transcription factors; Regulator genes; Similar protein; Molecular sequence data

Langue

anglais

Note

2019-12-05

Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-28

Format: MODS

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The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1 alpha and Drosophila single-minded

1996

Mots clés AGROVOC

Informations bibliographiques