The association of genetically determined serum glycine with cardiovascular risk in East Asians
2021
Chang, Xuling | Wang, Ling | Guan, Shou Ping | Kennedy, Brian K. | Liu, Jianjun | Khor, Chiea-Chuen | Low, Adrian F. | Chan, Mark Yan-Yee | Yuan, Jian-Min | Koh, Woon-Puay | Friedlander, Yechiel | Dorajoo, Rajkumar | Heng, Chew-Kiat
Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians.We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138).Our study, a first in East Asians, suggest a protective role of glycine against CAD.
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