Increasing membrane permeability of carboxylic acid-containing drugs using synthetic transmembrane anion transporters
2021
Salam, Rayhanus | Chowdhury, Surid Mohammad | Marshall, Sarah R. | Gneid, Hassan | Busschaert, Nathalie
In this manuscript, we show that small-molecule-based anion transporters can significantly increase the permeability of carboxylic acid containing drugs across lipid bilayers of model vesicles. Due to the drug-like characteristics of the transporters, this finding could not only have implications for drug delivery, but also hints towards potential drug–drug and drug–food interactions.
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