Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma
2011
Shi, Hai-yun | Lv, Fu-jing | Zhu, Sheng-tao | Wang, Qing-gang | Zhang, Shu-tian
COX-2 and 5-LOX are up-regulated in ESCC. This study aims to determine the efficacy of COX-2 inhibitor, 5-LOX inhibitor and their combination on ESCC. Nimesulide can suppress cell growth and promote apoptosis, accompanied with a decrease of PGE₂ production. AA861 has the similar effect with a down-regulation of LTB₄. In animal experiment, the tumor volumes in drug-treated groups were significantly smaller with the lowest rates of Ki-67 positive cells. In conclusion, either COX-2 inhibitor or 5-LOX inhibitor can suppress ESCC. Dual inhibition of COX-2 and 5-LOX pathway may present a superior anticancer efficacy to either inhibition of COX-2 or 5-LOX alone.
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