Dialkylzinc-mediated allylic polyfluoroarylation reaction
2015
Kurauchi, Daisuke | Hirano, Keiichi | Kato, Hisano | Saito, Tatsuo | Miyamoto, Kazunori | Uchiyama, Masanobu
We present an allylic polyfluoroarylation reaction with broad substrate scope and excellent functional group tolerance, using organozinc reagents under mild conditions. A catalytic amount of triphenylphosphine oxide efficiently promotes iodine–zinc exchange reaction between polyfluoroaryl iodide and dimethylzinc, and the resulting phosphine oxide-activated polyfluoroarylzinc undergoes substitution reaction with allylic halides to afford the corresponding polyfluoroarylated products.
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