Biofilm Changes of Clinically Isolated Coagulase Negative Staphylococci
2020
Soumya, K. R. | Jishma, P. | Sugathan, Sheela | Mathew, Jyothis | Radhakrishnan, E. K.
Coagulase Negative Staphylococci (CoNS) are remarkable for the heterogeneity in the chemical composition and structural architecture of its biofilm. The present study was aimed to investigate the impact of various factors on biofilm structure and composition of clinically isolated CoNS. Here, comparative microscopic analysis on CoNS biofilm was carried out under various physiological conditions. Quantitative and electron microscopic analysis of biofilm was conducted in the presence of different concentrations of glucose, NaCl, plasma and serum. From this, different CoNS strains were found to form its own pattern of biofilm in the presence of glucose or NaCl and also with respect to the biofilm-associated genes present. The growth conditions used in the study for the CoNS were shown to induce biofilm formation with the structural features designed by its genotype. The study gave insight into the fine modulation of CoNS biofilm structure in accordance with species, genetic basis and environmental conditions. Hence, the results can have clinical significance.
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