DNA-intercalation on pyrene modified surface coatings

LaibCurrent address: Department of Physics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA; E-mail: slaib@physics.ucsd.edu Stephan; KriegCurrent address: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK OX3 7BN Alexander; Häfliger, Pascal; Agorastos, Nikos

DNA-intercalation on pyrene modified surface coatings

2005

LaibCurrent address: Department of Physics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA; E-mail: [email protected] Stephan | KriegCurrent address: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK OX3 7BN Alexander | Häfliger, Pascal | Agorastos, Nikos

Utilising the strong affinity between nucleic acids and an intercalating pyrene derivate, a novel efficient method for unspecific immobilisation of double-stranded DNA on to solid support for applications in bioanalytic, biophysics and microbiology is presented.

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