Chlorine speciation analysis in blood by ion chromatography-inductively coupled plasma mass spectrometry
2015
Schwan, A. M. | Martin, R. | Goessler, W.
At present, chlorate salts are discussed as potential in vivo disinfectants in food animals. However, the ongoing metabolism studies rely on robust and sensitive methods. Therefore, a method for the determination of chlorine species in blood was developed. After their ion chromatographic separation, chlorate and chlorite were detected by single-quadrupole inductively coupled plasma mass spectrometry (IC-ICPMS). The suitability of the method was evaluated with spiking experiments. Estimated detection limits of ∼0.1 mg Cl L⁻¹ for chlorite and ∼0.2 mg Cl L⁻¹ for chlorate in measurement solutions (injection volume 20 μL) and ∼0.5 mg Cl L⁻¹ for chlorite and ∼1.0 mg Cl L⁻¹ for chlorate in blood were obtained. In order to overcome the interfering ¹⁸O¹⁶O¹H⁺ and ³⁶Ar¹H⁺ ions, IC was also coupled to a triple-quadruple ICPMS (ICPQQQMS) operating in MS/MS mode with hydrogen as reaction gas. However, the signal-to-background ratios and, hence, the detection limits could not be improved due to a constant chlorine background. However, with appropriate sample preparation, the method is suitable for the determination of anionic chlorine compounds in blood.
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