Topical Anti-Inflammatory Lignans from Haplophyllum hispanicum Haplophyllum hispanicum
2014
Prieto, J. M. | Recio, M. C. | Giner, R. M. | Máñez, S. | Massmanian, A. | Waterman, P. G. | Ríos, J. L.
The present paper reports the results of the methanol extract of Haplophyllum hispanicum Spach on single or repeated local 12-O-tetradecanoylphorbol acetate (TPA) administration and in the oxazolone-induced contact-delayed hypersensitivity mouse ear edemas. Two topical anti-inflammatory aryl naphthalide lignans were isolated from the active fractions of the methanol extract. They were identified by spectroscopic methods, including ¹³C NMR and heteronuclear multiple bond correlation (HMBC), as diphyllin acetyl apioside and tuberculatin. The former was the most active on acute TPA edema with a ID₅₀ of 0.27 μmol/ear
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