D-fenfluramine selectively suppresses carbohydrate snacking by obese subjects
1985
Wurtman, J. | Wurtman, R. | Mark, S. | Tsay, R. | Gilbert, W. | Growdon, J.
Extract: Twenty obese inpatients who claimed to crave carbohydrate-rich foods were given d-fenfluramine or its placebo, double-blind, for two consecutive eight-day periods. Food choices were measured on treatment days 1, 7, and 8 by giving the subjects access to unlimited portions of six isocaloric meal foods and of 10 isocaloric snack foods available 24 hours a day in a computerized vending machine. d-fenfluramine reduced mealtime carbohydrate by 22%, and had no significant effect on mealtime protein consumption; in contrast, snack calorie intake was reduced by 41%, and snack carbohydrate intake by the same proportion. The mean number of carbohydrate-rich snacks consumed per day decreased from 5.8 to 3.4, while that of protein-rich snacks failed to change significantly. (author)
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