Salivary gland extracts from the deerfly contain a potent inhibitor of platelet aggregation

Grevelink, S.A.; Youssef, D.E.; Loscalzo, J.; Lerner, E.A.

Salivary gland extracts from the deerfly contain a potent inhibitor of platelet aggregation

1993

Grevelink, S.A. | Youssef, D.E. | Loscalzo, J. | Lerner, E.A.

Salivary gland extracts of the deerfly contain a potent inhibitor of platelet aggregation, which assists the insect in obtaining a blood meal. The extract prevents platelet aggregation induced by ADP, thrombin, and collagen and inhibits fibrinogen binding to the glycoprotein IIb/IIIa receptor on platelets. The active component in deerfly salivary gland extract appears to be a protein that is comparatively more potent than the disintegrins present in viper venoms. Isolation and characterization of this protein may provide different directions in therapeutics and studies of normal platelet physiology

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Mots clés AGROVOC

adenosine diphosphate animals blood blood platelets blood platelets chrysops cytology diptera electrophoresis extracts fibrinogen hemostasis humans inhibition kinetics massachusetts metabolism molecular weight pharmacology physiology salivary glands salivary glands tissue extracts

Informations bibliographiques

Publié dans

Proceedings of the National Academy of Sciences of the United States of America

Volume 90 Numéro 19 Pagination 9155 - 9158 ISSN 0027-8424

D'autres materias

Isolation purification; Drug effects; Platelet aggregation; Insect-derived products; Polyacrylamide gel; Salivary proteins and peptides; Cyclic amp; Platelet aggregation inhibitors; Cyclic gmp; Platelet membrane glycoproteins; Cell separation; Apyrase; Therapeutics

Langue

anglais

Licence

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Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-28

Format: MODS

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Cette notice bibliographique a été fournie par National Agricultural Library

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Liens

DOI DOI http://dx.doi.org/10.1073/pnas.90.19.9155

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Salivary gland extracts from the deerfly contain a potent inhibitor of platelet aggregation

1993

Mots clés AGROVOC

Informations bibliographiques