Diastereodivergent Construction of Bicyclic γ-Lactones via Enantioselective Ketone Hydroacylation
2016
Wu, Xuesong | Chen, Zhiwei | Bai, Yu-Bin | Dong, Vy M.
We present a diastereodivergent strategy for constructing bicyclic γ-lactones bearing quaternary carbon centers via ketone hydroacylation. By applying a Rh catalyst and JoSPOphos ligand, either the anti or syn bicyclic γ-lactones can be accessed with high enantio- and diastereoselectivities, depending on the choice of solvent, temperature, and counterion.
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