Multi-step synthesis strategies towards 1,2-amino alcohols with special emphasis on phenylpropanolamines
2015
Sehl, Torsten | Maugeri, Zaira | Rother, Dörte
Chiral vicinal amino alcohols are molecules with broad applications in the pharmaceutical as well as in the chemical industry. Due to their high potential, various multi-step chemical, chemo-enzymatic and enzymatic reaction synthesis strategies have been developed within the last decades. This review summarises the asymmetric synthetic routes towards vicinal amino alcohols in general and provides exemplary in-depth looks into multi-step phenylpropanolamine synthesis with special focus on recently published cascade approaches.
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