Straub tail reaction in mice treated with σ₁ receptor antagonist in combination with methamphetamine
2012
Kitanaka, Junichi | Kitanaka, Nobue | Scott Hall, F. | Uhl, George R. | Tanaka, Koh-ichi | Nishiyama, Nobuyoshi | Takemura, Motohiko
Straub tail reaction (STR) was observed in male ddY mice after simultaneous administration with BMY 14802 (a non-specific σ receptor antagonist) and methamphetamine (METH). The intensity and duration of STR depended on the dose of BMY 14802. The tail reaction was inhibited completely by (+)-SKF 10,047 (a putative σ₁ receptor agonist) and partially by PB 28 (a putative σ₂ receptor agonist). The STR was mimicked in mice treated with BD 1047 (a putative σ₁ receptor antagonist), but not SM-21, a putative σ₂ receptor antagonist, in combination with METH. STR evoked with BD 1047 plus METH was inhibited by (+)-SKF 10,047. STR induced by BMY 14802 and METH was abolished by naloxone (a relatively non-selective opioid receptor antagonist) or U-50,488H (a selective κ-agonist), suggesting that the STR may be mediated by activation of opioid receptor system.
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