Expedited synthesis of benzofuran-2-carboxylic acids via microwave-assisted Perkin rearrangement reaction
2012
Marriott, Karla-Sue C. | Bartee, Rena | Morrison, Andrew Z. | Stewart, Leonard | Wesby, Julian
3-Halocoumarins are readily converted into benzofuran-2-carboxylic acids via a Perkin (coumarin–benzofuran ring contraction) rearrangement reaction. This rearrangement entails initial base catalyzed ring fission. The resulting phenoxide anion then attacks a vinyl halide to produce the final benzofuran moiety. We explored this reaction under microwave reaction conditions and were able to significantly reduce reaction times as well as obtain very high yields of a series of benzofuran-2-carboxylic acid derivatives.
Afficher plus [+] Moins [-]Mots clés AGROVOC
Informations bibliographiques
Cette notice bibliographique a été fournie par National Agricultural Library
Découvrez la collection de ce fournisseur de données dans AGRIS