Rh(III)-Catalyzed meta-C–H Olefination Directed by a Nitrile Template
2017
Xu, Hua-Jin | Lu, Yi | Farmer, Marcus E. | Wang, Huai-Wei | Zhao, Dan | Kang, Yan-Shang | Sun, Wei-Yin | Yu, Jin-Quan
A range of Rh(III)-catalyzed ortho-C–H functionalizations have been developed; however, extension of this reactivity to remote C–H functionalizations through large-ring rhodacyclic intermediates has yet to be demonstrated. Herein we report the first example of the use of a U-shaped nitrile template to direct Rh(III)-catalyzed remote meta-C–H activation via a postulated 12-membered macrocyclic intermediate. Because the ligands used for Rh(III) catalysts are significantly different from those of Pd(II) catalysts, this offers new opportunities for future development of ligand-promoted meta-C–H activation reactions.
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