Novel polymorphisms at codons 146 and 151 in the prion protein gene of Cyprus goats, and their association with natural scrapie
2007
Papasavva-Stylianou, P. | Kleanthous, M. | Toumazos, P. | Mavrikiou, P. | Loucaides, P.
To discern whether an association exists between specific combinations of polymorphisms of the prion protein (PrP) and natural scrapie in Cyprus goats, 250 goats were examined, including 164 histologically positive cases. Previously reported amino acid polymorphisms were detected at codons 154 (R leads to H), 168(P leads to Q), 220(Q leads to H) and 240 (S leads to P) and nucleotide alterations at codons 42 (a leads to g) and 138 (c leads to t). Additionally, novel amino acid polymorphisms were detected at codons 146 (N leads to S or D) and 151 (R leads to H) and new “silent” mutations were found at codons 179 (V, g leads to t), 181 (D, c leads to t) and 219 (T, c leads to t). The two novel polymorphisms at codon 146 were found only in the healthy control and scrapie-negative goats. By comparison, none of the scrapie-affected goats encoded these polymorphisms.
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