Life stage-dependent toxicities of 1-ethyl-3-methylimidazolium bromide on Caenorhabditis elegans
2020
Liu, Hong | Mo, Lingyun | Hou, Meifang | Zhang, Jing
Ionic liquids (ILs) are considered as extracting solvents in soil remediation. However, they can be pollutants themselves, and their own toxicities are of concerns. Notably, organisms were exposed to pollutants at random life stages in actual environmental exposure scenario, which is different from the set-up of one uniform life stage in usual experiment designs. The influence of life stages on ILs toxicities will provide essential information on their actual environmental risks. In the present study, effects of 1-ethyl-3-methylimidazolium bromide ([C₂mim]Br) were measured on C. elegans with egg exposure and adult exposure. In egg exposure, [C₂mim]Br increased the lifespan, stimulated initial reproduction and inhibited the total reproduction. Biochemical indices including oxidative stress, antioxidant responses and oxidative damage were further measured to explore the toxicity mechanisms. Results showed that [C₂mim]Br significantly stimulated O₂⁻· as the oxidative stress and superoxide dismutase (SOD) as the antioxidant defense. In adult exposure, [C₂mim]Br inhibited initial reproduction, total reproduction and lifespan. Biochemical results showed that [C₂mim]Br significantly stimulated H₂O₂ and oxidized glutathione (GSSG). The overall findings demonstrated that [C₂mim]Br caused life stage-dependent toxicities on C. elegans. Future studies are still needed for the detailed mechanisms.
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