Effects of pharmacological amounts of S-allylcysteine on lipids in normal and isoproterenol-induced myocardial infarction in rats
2006
Patmanāpan̲, M. | Prince, P.S.M.
The present study evaluates the effect of S-allylcysteine on marker enzymes, serum and myocardial lipids in normal and isoproterenol-induced myocardial infarction in male Wistar rats. A significant increase in the activities of marker enzymes such as creatine kinase, lactate dehydrogenase, aspartate transaminase and alanine transaminase in serum of isoproterenol (150 mg kg-1)-treated rats was observed. The levels of serum lipids (cholesterol, triglycerides, free fatty acids and phospholipids) were significantly increased, while the levels of myocardial cholesterol, triglycerides and free fatty acids were significantly increased in isoproterenol-administered rats. The concentration of myocardial phospholipids was significantly decreased in isoproterenol-administered rats. Oral pretreatment with S-allylcysteine at doses of 50, 100 and 150 mg kg-1 using an intragastric tube daily for a period of 45 days positively modulated the biochemical alterations caused by isoproterenol. The effect of S-allylcysteine at a dose of 150 mg kg-1 showed a better cardioprotective effect than the other two doses (50 and 100 mg kg-1). α-Tocopherol (60 mg kg-1) administration orally using an intragastric tube to rats daily for 45 days also exhibited a significant cardioprotective effect. The effect of S-allylcysteine was compared with α-tocopherol. Oral administration of S-allylcysteine (50, 100 and 150 mg kg-1) to normal rats did not show any significant change in this study. Thus, from the present study it can be concluded that a pharmacological dose of S-allylcysteine exerts a protective effect against isoproterenol-induced myocardial infarction in rats.
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