Suzuki cross-coupling of 5-bromothieno[2,3-b]pyridines for the convenient synthesis of 8-arylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amines
2013
Loidreau, Yvonnick | Levacher, Vincent | Besson, Thierry
For the first time, Suzuki cross-coupling reactions were used for introducing an aromatic group in position 8 of the pyridine ring of novel pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amines. This reliable and simple method may be extended to various boronic acids for allowing preparation of a larger library of these compounds in the hope of further structure–activity relationship investigations.
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