Changes in glutathione status and 3,5,3,'-triiodothyronine action in livers of rats given cysteine-deficient diets
1989
Garcin, H. | Suberville, C. | Higueret, P.
For a period of 32 d young rats were given a diet containing (g/kg) 220 casein, 120 casein + 1.93 L-cysteine (Cys), or 120 casein. The formation of 3,5,3,-triiodothyronine (T3)-nuclear protein complexes was reduced in rats fed on the Cys-deficient diet. Scatchard analysis showed that decreased formation of T 3-nuclear protein complexes was due to a decreased affinity of T3 receptors; this decrease was induced, at least in part, by a reduced glutathione content. In rats fed on the Cys-deficient diet there was an expected decrease in growth but an unexpected increase in the activities of glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) (EC 1.1.1.40). It suggested that this increase is related to an increased oxidized glutathione: reduced glutathione ratio.
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